Dr Thomas Spencer

Wallman, P., Estradé, E., Azis, M., Haining, K., Liang, X., Spencer, T.J., Diederen, K., Provenzani, U., Uhlhaas, P.J. & Fusar Poli, P. The ENTER Study (E-DetectioN Tool for Emerging Mental DisoRders): General Population Recruitment and Data Integrity in Online Screening for Psychosis Risk. (2025). Accepted for publication in Frontiers in Psychiatry, Volume 16, doi: 10.3389/fpsyt.2025.1665854

Lukow, P. B., Schubert, J. J., Severino, M., Knight, S. R., Kiemes, A., Livingston, N. R., Davies, J., de Micheli, A., Spencer, T. J., Fusar-Poli, P., Haege, B., Vorontsova, N., Donocik, J., Rabiner, E. A., Grace, A. A., Williams, S. C., McGuire, P., Veronese, M., Turkheimer, F. E., & Modinos, G. (2025). GABAA receptor availability in clinical high-risk and first-episode psychosis: a [11C]Ro15-4513 positron emission tomography study. Molecular Psychiatry, June. https://doi.org/10.1038/s41380-025-03204-9

Livingston, N. R., Kiemes, A., O’Daly, O., Knight, S. R., Lukow, P. B., Jelen, L. A., Reilly, T. J., Dima, A., Nettis, M. A., Casetta, C., Devenyi, G. A., Spencer, T., De Micheli, A., Fusar-Poli, P., Grace, A. A., Williams, S. C. R., McGuire, P., Chakravarty, M. M., Egerton, A., & Modinos, G. (2025). Diazepam modulates hippocampal CA1 functional connectivity in people at clinical high-risk for psychosis. Psychological Medicine, 55. https://doi.org/10.1017/S0033291725101268

Tognin, S., Vieira, S., Oliver, D., Cullen, A. E., Kempton, M. J., Fusar-Poli, P., Mechelli, A., Dazzan, P., Merritt, K., Maat, A., de Haan, L., Lawrie, S. M., van Amelsvoort, T., Arango, C., Nelson, B., Galderisi, S., Bressan, R., Kwon, J. S., Mizrahi, R., … McGuire, P. (2025). PSYSCAN multi-centre study: baseline characteristics and clinical outcomes of the clinical high risk for psychosis sample. Schizophrenia, 11(1), 1–9. https://doi.org/10.1038/s41537-025-00598-x

Gibbs-Dean, T., Katthagen, T., Hu, R., Westwater, M., Spencer, T., & Diederen, K. (2024). The joint estimation of uncertainty and its relationship with psychotic-like traits and psychometric schizotypy. https://scispace.com/papers/the-joint-estimation-of-uncertainty-and-its-relationship-4rdosjrefjoy

Slot, M. I. E., Urquijo Castro, M. F., Winter - van Rossum, I., van Hell, H. H., Dwyer, D., Dazzan, P., Maat, A., De Haan, L., Crespo-Facorro, B., Glenthøj, B. Y., Lawrie, S. M., McDonald, C., Gruber, O., van Amelsvoort, T., Arango, C., Kircher, T., Nelson, B., Galderisi, S., Weiser, M., … Kahn, R. S. (2024). Multivariable prediction of functional outcome after first-episode psychosis: a crossover validation approach in EUFEST and PSYSCAN. Schizophrenia, 10(1). https://doi.org/10.1038/s41537-024-00505-w

Liang, X., Avram, M. M., Gibbs-Dean, T., Chesney, E., Oliver, D., Wang, S., Obreshkova, S., Spencer, T., Englund, A., & Diederen, K. (2024). Exploring the relationship between frequent cannabis use, belief updating under uncertainty and psychotic-like symptoms. Frontiers in Psychiatry, 15(July), 1–12. https://doi.org/10.3389/fpsyt.2024.1309868

Livingston, N. R., Kiemes, A., Devenyi, G. A., Knight, S., Lukow, P. B., Jelen, L. A., Reilly, T., Dima, A., Nettis, M. A., Casetta, C., Agyekum, T., Zelaya, F., Spencer, T., De Micheli, A., Fusar-Poli, P., Grace, A. A., Williams, S. C. R., McGuire, P., Egerton, A., … Modinos, G. (2024). Effects of diazepam on hippocampal blood flow in people at clinical high risk for psychosis. Neuropsychopharmacology, 49(9), 1448–1458. https://doi.org/10.1038/s41386-024-01864-9

Olah, J., Cummins, N., Arribas, M., Gibbs-Dean, T., Molina, E., Sethi, D., Kempton, M. J., Morgan, S., Spencer, T., & Diederen, K. (2024). Towards a scalable approach to assess speech organization across the psychosis-spectrum -online assessment in conjunction with automated transcription and extraction of speech measures. Translational Psychiatry, 14(1), 1–11. https://doi.org/10.1038/s41398-024-02851-w

Olah, J., Diederen, K., Gibbs-Dean, T., Kempton, M. J., Dobson, R., Spencer, T., & Cummins, N. (2023). Online speech assessment of the psychotic spectrum: Exploring the relationship between overlapping acoustic markers of schizotypy, depression and anxiety. Schizophrenia Research, 259(April), 11–19. https://doi.org/10.1016/j.schres.2023.03.044

Olah, J., Spencer, T., Cummins, N., & Diederen, K. (2023). Automated analysis of speech as a marker of sub-clinical psychotic experiences. Frontiers in Psychiatry, 14(February), 1–12. https://doi.org/10.3389/fpsyt.2023.1265880

Del Piccolo, M. C., Valmaggia, L., Henderson, C., Spencer, T. J., Lewis, D., Fitzell, S., Edwards, S., Evans, C., & Tognin, S. (2023). Individual placement and support focusing on employment and education for young people at clinical high risk of psychosis: A feasibility study. Psychiatric Rehabilitation Journal, 47(1), 56–63. https://doi.org/10.1037/prj0000585

Nettekoven, C. R., Diederen, K., Giles, O., Duncan, H., Stenson, I., Olah, J., Gibbs-Dean, T., Collier, N., Vértes, P. E., Spencer, T. J., Morgan, S. E., & McGuire, P. (2023). Semantic Speech Networks Linked to Formal Thought Disorder in Early Psychosis. Schizophrenia Bulletin, 49, S142–S152. https://doi.org/10.1093/schbul/sbac056

Gibbs-Dean, T., Katthagen, T., Tsenkova, I., Ali, R., Liang, X., Spencer, T., & Diederen, K. (2023). Belief updating in psychosis, depression and anxiety disorders: A systematic review across computational modelling approaches. Neuroscience and Biobehavioral Reviews, 147(February), 105087. https://doi.org/10.1016/j.neubiorev.2023.105087

Estradé, A., Spencer, T. J., De Micheli, A., Murguia-Asensio, S., Provenzani, U., McGuire, P., & Fusar-Poli, P. (2023). Mapping the implementation and challenges of clinical services for psychosis prevention in England. Frontiers in Psychiatry, 13. https://doi.org/10.3389/fpsyt.2022.945505

Kirschner, M., Hodzic-Santor, B., Antoniades, M., Nenadic, I., Kircher, T., Krug, A., Meller, T., Grotegerd, D., Fornito, A., Arnatkeviciute, A., Bellgrove, M. A., Tiego, J., Dannlowski, U., Koch, K., Hülsmann, C., Kugel, H., Enneking, V., Klug, M., Leehr, E. J., … Modinos, G. (2022). Cortical and subcortical neuroanatomical signatures of schizotypy in 3004 individuals assessed in a worldwide ENIGMA study. Molecular Psychiatry, 27(2), 1167–1176. https://doi.org/10.1038/s41380-021-01359-9

Nuzum, E., Hammoud, R., Spencer, T., Akande, I., & Tognin, S. (2022). No rest for the weary: Prevalence, impact and nature of sleep problems among young people at risk of psychosis. Early Intervention in Psychiatry, 16(6), 651–658. https://doi.org/10.1111/eip.13210

Morgan, S. E., Diederen, K., Vértes, P. E., Ip, S. H. Y., Wang, B., Thompson, B., Demjaha, A., De Micheli, A., Oliver, D., Liakata, M., Fusar-Poli, P., Spencer, T. J., & McGuire, P. (2021). Natural Language Processing markers in first episode psychosis and people at clinical high-risk. Translational Psychiatry, 11(1). https://doi.org/10.1038/s41398-021-01722-y

Spencer, Tom John, Thompson, B., Oliver, D., Diederen, K., Demjaha, A., Weinstein, S., Morgan, S. E., Day, F., Valmaggia, L., Rutigliano, G., De Micheli, A., Mota, N. B., Fusar-Poli, P., & McGuire, P. (2021). Lower speech connectedness linked to incidence of psychosis in people at clinical high risk. Schizophrenia Research, 228, 493–501. https://doi.org/10.1016/j.schres.2020.09.002

Haarsma, J., Fletcher, P. C., Griffin, J. D., Taverne, H. J., Ziauddeen, H., Spencer, T. J., Miller, C., Katthagen, T., Goodyer, I., Diederen, K. M. J., & Murray, G. K. (2021). Precision weighting of cortical unsigned prediction error signals benefits learning, is mediated by dopamine, and is impaired in psychosis. Molecular Psychiatry, 26(9), 5320–5333. https://doi.org/10.1038/s41380-020-0803-8

Jauhar, S., Lai, S., Bonoldi, I., Salazar de Pablo, G., di Forti, M., Alameda, L., Donocik, J., Iacoponi, E., Spencer, T., Haege, B., McLaughlan, D., Taylor, D., Young, A. H., Thornicroft, G., Gaughran, F., MacCabe, J. H., Murray, R. M., McGuire, P., & Fusar-Poli, P. (2021). Early intervention in psychosis during the COVID-19 pandemic: Maudsley recommendations. European Neuropsychopharmacology, 47(February), 130–135. https://doi.org/10.1016/j.euroneuro.2021.02.005

Fusar-Poli, P., Spencer, T., De Micheli, A., Curzi, V., Nandha, S., & McGuire, P. (2020). Outreach and support in South-London (OASIS) 2001—2020: Twenty years of early detection, prognosis and preventive care for young people at risk of psychosis. European Neuropsychopharmacology, 39, 111–122.

Fusar-Poli, P., de Micheli, A., Patel, R., Signorini, L., Miah, S., Spencer, T., & McGuire, P. (2020). Real-World clinical outcomes two years after transition to psychosis in individuals at clinical high risk: Electronic health record cohort study. Schizophrenia Bulletin, 46(5), 1114–1125. https://doi.org/10.1093/schbul/sbaa040

Tognin, S., Grady, L., Ventura, S., Valmaggia, L., Sear, V., Mcguire, P., Fusar-poli, P., & Spencer, T. J. (2019). The Provision of Education and Employment Support At the Outreach and Support in South London (OASIS ) Service for People at Clinical High Risk for Psychosis. 10(November), 1–9.

Tognin, S., van Hell, H. H., Merritt, K., Winter-van Rossum, I., Bossong, M. G., Kempton, M. J., Modinos, G., Fusar-Poli, P., Mechelli, A., Dazzan, P., Maat, A., de Haan, L., Crespo-Facorro, B., Glenthøj, B., Lawrie, S. M., McDonald, C., Gruber, O., van Amelsvoort, T., Arango Lopez, C., … Morgan, S. (2019). Towards Precision Medicine in Psychosis: Benefits and Challenges of Multimodal Multicenter Studies—PSYSCAN: Translating Neuroimaging Findings From Research into Clinical Practice. Schizophrenia Bulletin, 1–10. https://doi.org/10.1093/schbul/sbz067

Fusar-Poli, P., Estradé, A., Spencer, T. J., Gupta, S., Murguia-Asensio, S., Eranti, S., Wilding, K., Andlauer, O., Buhagiar, J., Smith, M., Fitzell, S., Sear, V., Ademan, A., De Micheli, A., & McGuire, P. (2019). Pan-London Network for Psychosis-Prevention (PNP). Frontiers in Psychiatry, 10(October), 1–10. https://doi.org/10.3389/fpsyt.2019.00707

Diederen, K. M. J., Ziauddeen, H., Vestergaard, M. D., Spencer, T., Schultz, W., & Fletcher, P. C. (2017). Dopamine Modulates Adaptive Prediction Error Coding in the Human Midbrain and Striatum. The Journal of Neuroscience, 37(7), 1708–1720. https://doi.org/10.1523/JNEUROSCI.1979-16.2016

Diederen, K. M. M. J., Spencer, T., Vestergaard, M. D. D., Fletcher, P. C. C., & Schultz, W. (2016). Adaptive Prediction Error Coding in the Human Midbrain and Striatum Facilitates Behavioral Adaptation and Learning Efficiency. Neuron, 90(5), 1127–1138. https://doi.org/10.1016/j.neuron.2016.04.019

Cueva, C., Roberts, R. E., Spencer, T. J., Rani, N., Tempest, M., Tobler, P. N., Herbert, J., & Rustichini, A. (2017). Testosterone administration does not affect men’s rejections of low ultimatum game offers or aggressive mood. Hormones and Behavior, 87, 1–7. https://doi.org/10.1016/j.yhbeh.2016.09.012

Cueva, C., Roberts, R. E., Spencer, T., Rani, N., Tempest, M., Tobler, P. N., Herbert, J., & Rustichini, A. (2015). Cortisol and testosterone increase financial risk taking and may destabilize markets. Scientific Reports, 5, 1–16. https://doi.org/10.1038/srep11206

Spencer, T.J., Sule, J., Brown, N., Farrington, M., Aliyu, S. & Ludlum H. (2011). An audit of blood culture standards. The Royal College of Pathologists, 153:68–70.

Spencer, Tom J., Montaldi, D., Gong, Q. Y., Roberts, N., & Mayes, A. R. (2009). Object priming and recognition memory: Dissociable effects in left frontal cortex at encoding. Neuropsychologia, 47(13), 2942–2947.

Montaldi, D., Spencer, T.J., Roberts, N. & Mayes, A.R. (2006). The neural system that mediates familiarity memory. Hippocampus, 16:504–520.

Mayes, A. R., Montaldi, D., Spencer, T. J., & Roberts, N. (2004). Recalling spatial information as a component of recently and remotely acquired episodic or semantic memories: An fMRI study. Neuropsychology, 18(3), 426–441. https://doi.org/10.1037/0894-4105.18.3.426